In "The Whisperer in Darkness," Albert N. Wilmarth, an instructor of literature at Miskatonic University, gets caught up in a controversy surrounding strange sightings during a flood in Vermont. He aligns himself with the skeptics, attributing the sightings to old legends of abductions by monsters in the hills. However, his perspective begins to shift when he receives a letter from Henry Wentworth Akeley, a man living in an isolated farmhouse in Vermont. Akeley claims to have proof that will convince Wilmarth of the existence of otherworldly beings.

As their correspondence unfolds, Akeley shares accounts of an extraterrestrial race joining forces with human agents to worship powerful entities like Cthulhu and Nyarlathotep. The agents intercept Akeley's messages and relentlessly terrorize his farmhouse, leading to a violent confrontation resulting in casualties on both sides. In a shocking twist, Akeley, who initially opposed the creatures, suddenly expresses a change of heart, claiming that they are peaceful and have revealed unimaginable wonders to him.

Despite his reservations, Wilmarth agrees to visit Akeley and see the evidence firsthand. However, when he arrives at the farmhouse, he finds Akeley in a deteriorated state, confined to a chair in darkness. Akeley reveals to Wilmarth that the extraterrestrial beings can extract human brains and preserve them in canisters to withstand the harshness of space travel. Akeley himself has decided to embark on this journey and points to a canister bearing his name, indicating his readiness to leave for Yuggoth, the beings' outpost on Pluto.

During their conversations, Wilmarth becomes increasingly uneasy, particularly due to Akeley's strange buzzing whispering. This unease intensifies when Wilmarth overhears a disturbing conversation among multiple voices, some sounding eerie and alien. Investigating further, Wilmarth discovers that Akeley has vanished, leaving behind only his discarded robe. In a chilling revelation, hidden within the folds of the robe, Wilmarth finds the horrifying remains of Akeley's face and hands, suggesting that a malevolent entity had assumed his appearance.

In the aftermath, the authorities find nothing but a destroyed house, devoid of any physical evidence of the extraterrestrial presence. Wilmarth, however, is haunted by the certainty that the cylinder in the dark room contained Akeley's brain, already consumed and controlled by a sinister force.

"The Whisperer in Darkness" takes readers on a journey filled with mystery and cosmic horror. As Wilmarth delves deeper into the chilling revelations surrounding the extraterrestrial beings and their influence on humanity, he unravels a disturbing truth that surpasses all imagination. Lovecraft's masterful storytelling and skillful buildup of suspense keep readers on the edge of their seats, making "The Whisperer in Darkness" a true literary masterpiece in the realm of speculative fiction.